Conformational Dynamics of a Single Protein Monitored for 24 h at Video Rate

A Full-Fuzzy Rate Controller for Variable Bit Rate Video

In this paper, we propose a new full-fuzzy video ratecontrol algorithm (RCA) for variable bit rate (VBR) videoapplications. The proposed RCA provides high qualitycompressed video with a low degree computational complexity.By controlling the quantization parameter (QP) on a picturebasis, it produces VBR video bit streams. The proposed RCAhas been implemented on the JM H.264/AVC video codec andth...

Single-molecule fluorescence studies of protein folding and conformational dynamics.

Conformational dynamics of single G protein-coupled receptors in solution.

G protein-coupled receptors (GPCRs) comprise a large family of seven-helix transmembrane proteins which regulate cellular signaling by sensing light, ligands, and binding proteins. The GPCR activation process, however, is not a simple on-off switch; current models suggest a complex conformational landscape in which the active, signaling state includes multiple conformations with similar downstr...

Protein conformational dynamics probed by single-molecule electron transfer.

Electron transfer is used as a probe for angstrom-scale structural changes in single protein molecules. In a flavin reductase, the fluorescence of flavin is quenched by a nearby tyrosine residue by means of photo-induced electron transfer. By probing the fluorescence lifetime of the single flavin on a photon-by-photon basis, we were able to observe the variation of flavin-tyrosine distance over...

Conformational dynamics data bank: a database for conformational dynamics of proteins and supramolecular protein assemblies

The conformational dynamics data bank (CDDB, http://www.cdyn.org) is a database that aims to provide comprehensive results on the conformational dynamics of high molecular weight proteins and protein assemblies. Analysis is performed using a recently introduced coarse-grained computational approach that is applied to the majority of structures present in the electron microscopy data bank (EMDB)...